Frequent detection of pancreatic lesions in asymptomatic high-risk individuals.

ABSTRACT:

Background & aims

The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neoplasms, but the optimal imaging approach is not known. We determined the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals (HRIs).

Methods

We screened 225 asymptomatic adult HRIs at 5 academic US medical centers once, using computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasonography (EUS). We compared results in a blinded, independent fashion.

Results

Ninety-two of 216 HRIs (42%) were found to have at least 1 pancreatic mass (84 cystic, 3 so

SUBMITTER: Canto MI 

PROVIDER: S-EPMC3321068 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature