Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.

ABSTRACT:

Background & aims

Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression.

Methods

We combined data from high-resolution, array-based comparative genomic hybridization and transcriptome analysis of HCC samples from 76 patients with hepatitis B virus infection with data on patient survival times. Candidate genes were functionally validated using in vitro and in vivo models.

Results

Unsupervised analyses of array comparative genomic hybridization data associated loss of chromosome 8p with poor outcome (reduced survival time); somatic copy number alt

SUBMITTER: Roessler S 

PROVIDER: S-EPMC3321110 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature