Perfluorooctanoic acid exposure and pregnancy outcome in a highly exposed community.

ABSTRACT:

Background

We assessed the association between perfluorooctanoic acid (PFOA) and pregnancy outcome in an area with elevated exposure to PFOA from drinking water contaminated by chemical plant releases.

Methods

Serum PFOA was measured, and reproductive and residential histories were obtained during 2005-2006. We estimated serum PFOA levels at the time of pregnancy for 11,737 pregnancies occurring between 1990 and 2006, based on historical information on PFOA releases, environmental distribution, pharmacokinetic modeling, and residential histories. We assessed the association between PFOA and the odds of miscarriage, stillbirth, preeclampsia, preterm birth, term low birthweight, and birth defects, controlling for calendar time, age, parity, education, and smoking. PFOA exposur

SUBMITTER: Savitz DA 

PROVIDER: S-EPMC3321117 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature