Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?

ABSTRACT:

Objective

To investigate the potential effects of lifetime cumulative ozone (O3) exposure on acute pulmonary responses to O3.

Methods

Fifteen healthy subjects from a larger cohort of young adults were exposed to 200 ppb O3 for 4 hours followed by bronchoscopy and bronchoalveolar lavage 18 hours later. Lung function, symptom questionnaires, and blood samples were obtained before and after each exposure. Subjects' lifetime cumulative O3 exposures were estimated from residential histories and air-quality monitoring data.

Results

Acute exposure to O3 caused decrements in forced expiratory volume in 1 second (FEV1), maximal mid-expiratory flow rate (FEF25-75), and forced expiratory flow rate at 75% of forced vital capacity (FEF75), and an increase in plasma clara cell prot

SUBMITTER: Arjomandi M 

PROVIDER: S-EPMC3321313 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature