PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.

ABSTRACT: Autophagy, a process in which cellular components are engulfed and degraded within double-membrane vesicles termed autophagosomes, has an important role in the response to oxidative damage. Here we identify a novel cascade of phosphorylation events, involving a network of protein and lipid kinases, as crucial components of the signaling pathways that regulate the induction of autophagy under oxidative stress. Our findings show that both the tumor-suppressor death-associated protein kinase (DAPk) and protein kinase D (PKD), which we previously showed to be phosphorylated and consequently activated by DAPk, mediate the induction of autophagy in response to oxidative damage. Furthermore, we map the position of PKD within the autophagic network to Vps34, a lipid kinase whose function is indisp

SUBMITTER: Eisenberg-Lerner A 

PROVIDER: S-EPMC3321617 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature