Conservation of tubulin-binding sequences in TRPV1 throughout evolution.

ABSTRACT:

Background

Transient Receptor Potential Vanilloid sub type 1 (TRPV1), commonly known as capsaicin receptor can detect multiple stimuli ranging from noxious compounds, low pH, temperature as well as electromagnetic wave at different ranges. In addition, this receptor is involved in multiple physiological and sensory processes. Therefore, functions of TRPV1 have direct influences on adaptation and further evolution also. Availability of various eukaryotic genomic sequences in public domain facilitates us in studying the molecular evolution of TRPV1 protein and the respective conservation of certain domains, motifs and interacting regions that are functionally important.

Methodology and principal findings

Using statistical and bioinformatics tools, our analysis reveals that TRP

SUBMITTER: Sardar P 

PROVIDER: S-EPMC3322131 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature