The GTPase activating Rap/RanGAP domain-like 1 gene is associated with chicken reproductive traits.

ABSTRACT:

Background

Abundant evidence indicates that chicken reproduction is strictly regulated by the hypothalamic-pituitary-gonad (HPG) axis, and the genes included in the HPG axis have been studied extensively. However, the question remains as to whether any other genes outside of the HPG system are involved in regulating chicken reproduction. The present study was aimed to identify, on a genome-wide level, novel genes associated with chicken reproductive traits.

Methodology/principal finding

Suppressive subtractive hybridization (SSH), genome-wide association study (GWAS), and gene-centric GWAS were used to identify novel genes underlying chicken reproduction. Single marker-trait association analysis with a large population and allelic frequency spectrum analysis were used to con

SUBMITTER: Shen X 

PROVIDER: S-EPMC3322132 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature