Intact relational memory and normal hippocampal structure in the early stage of psychosis.

ABSTRACT:

Background

Previous studies indicate that the transition to psychosis is associated with dynamic changes of hippocampal integrity. Here we explored hippocampal volume and neural activation during a relational memory task in patients who were in the early stage of a psychotic illness.

Methods

Forty-one early psychosis patients and 34 healthy control subjects completed a transitive inference (TI) task used previously in chronic schizophrenia patients. Participants learned to select the "winner" of two sets of stimulus pairs drawn from an overlapping sequence (A > B > C > D > E) and a nonoverlapping set (a > b, c > d, e > f, g > h). During a functional magnetic resonance imaging scan, participants were tested on the trained pairs and made inferential judgments on novel pairings

SUBMITTER: Williams LE 

PROVIDER: S-EPMC3322647 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature