PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents.

ABSTRACT:

Background

Reward behavior in animals is influenced by circadian genes, including clock-pathway genes such as Period2 (PER2). Several forms of psychiatric illness are associated with both altered reward function and disturbances in circadian function. The PER2 single nucleotide polymorphism (SNP) rs2304672 has been associated with psychiatric illnesses involving reward dysfunction. Associations among circadian genes, function in neural reward circuits, and circadian-influenced behavior have not yet been studied in humans, however.

Methods

90 healthy adolescents underwent functional magnetic resonance imaging during a guessing task with monetary reward, genotyping for two PER2 SNPs (rs2304672, rs2304674), and actigraphy to measure sleep in their home environments. Weekend sle

SUBMITTER: Forbes EE 

PROVIDER: S-EPMC3323120 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature