Identification of a biomarker panel for colorectal cancer diagnosis.

ABSTRACT:

Background

Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most frequent and deadly neoplasias in the western countries.

Methods

A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60-mer oligo microarrays. The results obtained were validated by qRT-PCR. In the subsequent bioinformatics analysis, gene networks by means of Bayesian classifiers, variable selection and bo

SUBMITTER: Garcia-Bilbao A 

PROVIDER: S-EPMC3323359 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature