Analysis of the SOS response of Vibrio and other bacteria with multiple chromosomes.

ABSTRACT:

Background

The SOS response is a well-known regulatory network present in most bacteria and aimed at addressing DNA damage. It has also been linked extensively to stress-induced mutagenesis, virulence and the emergence and dissemination of antibiotic resistance determinants. Recently, the SOS response has been shown to regulate the activity of integrases in the chromosomal superintegrons of the Vibrionaceae, which encompasses a wide range of pathogenic species harboring multiple chromosomes. Here we combine in silico and in vitro techniques to perform a comparative genomics analysis of the SOS regulon in the Vibrionaceae, and we extend the methodology to map this transcriptional network in other bacterial species harboring multiple chromosomes.

Results

Our analysis provides

SUBMITTER: Sanchez-Alberola N 

PROVIDER: S-EPMC3323433 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature