Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei.

ABSTRACT:

Background

Glycosomes are a specialized form of peroxisomes (microbodies) present in unicellular eukaryotes that belong to the Kinetoplastea order, such as Trypanosoma and Leishmania species, parasitic protists causing severe diseases of livestock and humans in subtropical and tropical countries. The organelles harbour most enzymes of the glycolytic pathway that is responsible for substrate-level ATP production in the cell. Glycolysis is essential for bloodstream-form Trypanosoma brucei and enzymes comprising this pathway have been validated as drug targets. Glycosomes are surrounded by a single membrane. How glycolytic metabolites are transported across the glycosomal membrane is unclear.

Methods/principal findings

We hypothesized that glycosomal membrane, similarly to memb

SUBMITTER: Gualdron-Lopez M 

PROVIDER: S-EPMC3323538 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature