Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells.

ABSTRACT:

Background

Shedding microvesicles are membrane released vesicles derived directly from the plasma membrane. Exosomes are released membrane vesicles of late endosomal origin that share structural and biochemical characteristics with prostasomes. Microvesicles/exosomes can mediate messages between cells and affect various cell-related processes in their target cells. We describe newly detected microvesicles/exosomes from cardiomyocytes and depict some of their biological functions.

Methodology/principal findings

Microvesicles/exosomes from media of cultured cardiomyocytes derived from adult mouse heart were isolated by differential centrifugation including preparative ultracentrifugation and identified by transmission electron microscopy and flow cytometry. They were surrounde

SUBMITTER: Waldenstrom A 

PROVIDER: S-EPMC3323564 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature