Identification and analysis of flagellar coexpressed determinants (Feds) of Campylobacter jejuni involved in colonization.

ABSTRACT: The flagellum of Campylobacter jejuni provides motility essential for commensal colonization of the intestinal tract of avian species and infection of humans resulting in diarrhoeal disease. Additionally, the flagellar type III secretion system has been reported to secrete proteins such as CiaI that influence invasion of human intestinal cells and possibly pathogenesis. The flagellar regulatory system ultimately influences σ(28) activity required for expression of the FlaA major flagellin and other flagellar filament proteins. In this work, we discovered that transcription of ciaI and four genes we propose annotating as feds (for flagellar coexpressed determinants) is dependent upon σ(28) , but these genes are not required for motility. Instead, the Feds and CiaI are involved in commensal

SUBMITTER: Barrero-Tobon AM 

PROVIDER: S-EPMC3323700 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature