A large study reveals no association between APOE and Parkinson's disease.

ABSTRACT:

Background

Research focusing on the role of APOE in Parkinson's disease (PD) has been largely inconclusive, creating a broad discrepancy in association studies.

Objective

To elucidate the role of APOE alleles in PD risk by studying a large sample size and controlling for population substructure.

Patients and methods

In total, 3465 case and control samples were genotyped, obtained from the NINDS Neurogenetics repository.

Results

No significant differences in ε4 dosages exist between PD cases and controls. The frequency of ε4 carriers differed slightly between cases and controls at 24% (580/2412) and 26% (270/1053), respectively. Likewise, mean dosages of APOE ε2 were not significantly different between cases and controls. APOE ε2 carriers were observed at a freq

SUBMITTER: Federoff M 

PROVIDER: S-EPMC3323723 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature