Ontology highlight
ABSTRACT:
SUBMITTER: Hong SH
PROVIDER: S-EPMC3323757 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Hong Seok Hoon SH Wang Xiaoxue X O'Connor Hazel F HF Benedik Michael J MJ Wood Thomas K TK
Microbial biotechnology 20120106 4
Since persister cells cause chronic infections and since Escherichia coli toxin MqsR increases persisters, we used protein engineering to increase the toxicity of MqsR to gain insights into persister cell formation. Through two amino acid replacements that increased the stability of MqsR, toxicity and persistence were increased. A whole-transcriptome study revealed that the MqsR variant increased persistence by repressing genes for acid resistance, multidrug resistance and osmotic resistance. Co ...[more]