Temporally tuned neuronal differentiation supports the functional remodeling of a neuronal network in Drosophila.

ABSTRACT: During insect metamorphosis, neuronal networks undergo extensive remodeling by restructuring their connectivity and recruiting newborn neurons from postembryonic lineages. The neuronal network that directs the essential behavior, ecdysis, generates a distinct behavioral sequence at each developmental transition. Larval ecdysis replaces the cuticle between larval stages, and pupal ecdysis externalizes and expands the head and appendages to their adult position. However, the network changes that support these differences are unknown. Crustacean cardioactive peptide (CCAP) neurons and the peptide hormones they secrete are critical for ecdysis; their targeted ablation alters larval ecdysis progression and results in a failure of pupal ecdysis. In this study, we demonstrate that the CCAP neuron

SUBMITTER: Veverytsa L 

PROVIDER: S-EPMC3324015 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature