Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.

ABSTRACT: Defining the function of the genes that, like RUNX1, are deregulated in blood cell malignancies represents an important challenge. Myeloid leukemia factors (MLFs) constitute a poorly characterized family of conserved proteins whose founding member, MLF1, has been associated with acute myeloid leukemia in humans. To gain insight into the functions of this family, we investigated the role of the Drosophila MLF homolog during blood cell development. Here we report that mlf controls the homeostasis of the Drosophila hematopoietic system. Notably, mlf participates in a positive feedback loop to fine tune the activity of the RUNX transcription factor Lozenge (LZ) during development of the crystal cells, one of the two main blood cell lineages in Drosophila. At the molecular level, our data in ce

SUBMITTER: Bras S 

PROVIDER: S-EPMC3324030 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature