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Palladium-catalyzed hydrofunctionalization of vinyl phenol derivatives with heteroaromatics.

ABSTRACT: A hydroheteroarylation reaction of vinyl phenols using an alkyl chloride as the sacrificial hydride source is reported. The method tolerates a wide range of heterocycles as the exogenous nucleophile including indoles and pyrroles. The resulting products are easily processed to biologically relevant scaffolds.

SUBMITTER: Pathak TP

PROVIDER: S-EPMC3324091 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Palladium-catalyzed hydrofunctionalization of vinyl phenol derivatives with heteroaromatics.

Pathak Tejas P TP Sigman Matthew S MS

Organic letters 20110421 10

A hydroheteroarylation reaction of vinyl phenols using an alkyl chloride as the sacrificial hydride source is reported. The method tolerates a wide range of heterocycles as the exogenous nucleophile including indoles and pyrroles. The resulting products are easily processed to biologically relevant scaffolds. ...[more]

PMID: 21510631

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