Gene coexpression network topology of cardiac development, hypertrophy, and failure.

ABSTRACT:

Background

Network analysis techniques allow a more accurate reflection of underlying systems biology to be realized than traditional unidimensional molecular biology approaches. Using gene coexpression network analysis, we define the gene expression network topology of cardiac hypertrophy and failure and the extent of recapitulation of fetal gene expression programs in failing and hypertrophied adult myocardium.

Methods and results

We assembled all myocardial transcript data in the Gene Expression Omnibus (n=1617). Because hierarchical analysis revealed species had primacy over disease clustering, we focused this analysis on the most complete (murine) dataset (n=478). Using gene coexpression network analysis, we derived functional modules, regulatory mediators, and higher-o

SUBMITTER: Dewey FE 

PROVIDER: S-EPMC3324316 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature