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PNA HyBeacons for analysis of human mutations related to statin-induced myopathy.

ABSTRACT: Aminoalkyl and alkyne-tagged PNA HyBeacons have been synthesized, labeled with fluorescein via conventional amide bond or triazole formation (click chemistry) and used to detect single nucleotide polymorphisms (SNPs) implicated in statin-induced myopathy. The PNA HyBeacons gave much better mismatch/mutant discrimination than conventional DNA HyBeacons but smaller fluorescence changes on melting.

SUBMITTER: Gale N 

PROVIDER: S-EPMC3324338 | biostudies-literature | 2011 Jul-Dec

REPOSITORIES: biostudies-literature

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PNA HyBeacons for analysis of human mutations related to statin-induced myopathy.

Gale Nittaya N   Kocalka Petr P   Mardle Charlotte C   Brown Tom T  

Artificial DNA, PNA & XNA 20110701 3

Aminoalkyl and alkyne-tagged PNA HyBeacons have been synthesized, labeled with fluorescein via conventional amide bond or triazole formation (click chemistry) and used to detect single nucleotide polymorphisms (SNPs) implicated in statin-induced myopathy. The PNA HyBeacons gave much better mismatch/mutant discrimination than conventional DNA HyBeacons but smaller fluorescence changes on melting. ...[more]

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