Genetic diversity in the block 2 region of the merozoite surface protein-1 of Plasmodium falciparum in central India.

ABSTRACT:

Background

Malaria continues to be a significant health problem in India. Several of the intended Plasmodium falciparum vaccine candidate antigens are highly polymorphic. The genetic diversity of P. falciparum merozoite surface protein-1 (MSP-1) has been extensively studied from various parts of the world. However, limited data are available from India. The aim of the present study was a molecular characterization of block 2 region of MSP-1 gene from the tribal-dominated, forested region of Madhya Pradesh.

Methods

DNA sequencing analysis was carried out in 71 field isolates collected between July 2005 to November 2005 and in 98 field isolates collected from July 2009 to December 2009. Alleles identified by DNA sequencing were aligned with the strain 3D7 and polymorphism anal

SUBMITTER: Bharti PK 

PROVIDER: S-EPMC3324372 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature