Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients.

ABSTRACT: There are 516 known kinases in the human genome. Because of their important role maintaining proper cellular function, they are often misregulated during tumorigenesis and associated with clinical outcomes in cancer patients, including clear cell renal cell carcinoma (ccRCC). However, less is known about the global expression status of these genes in renal cell carcinoma and their association with clinical outcomes. We performed a systematic analysis of gene expression for 503 kinases in 93 tumor samples and adjacent normal tissues. Expression patterns for 41 kinases were able to clearly differentiate tumor and normal samples. Expression of I-kappa-B kinase epsilon (IKBKE) was associated with a 5.3-fold increased risk of dying [95% confidence interval (CI): 1.93-14.59, P-value: 0.0012]. In

SUBMITTER: Hildebrandt MA 

PROVIDER: S-EPMC3324439 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature