Genes involved in systemic and arterial bed dependent atherosclerosis--Tampere Vascular study.

ABSTRACT:

Background

Atherosclerosis is a complex disease with hundreds of genes influencing its progression. In addition, the phenotype of the disease varies significantly depending on the arterial bed.

Methodology/principal findings

We characterized the genes generally involved in human advanced atherosclerotic (AHA type V-VI) plaques in carotid and femoral arteries as well as aortas from 24 subjects of Tampere Vascular study and compared the results to non-atherosclerotic internal thoracic arteries (n=6) using genome-wide expression array and QRT-PCR. In addition we determined genes that were typical for each arterial plaque studied. To gain a comprehensive insight into the pathologic processes in the plaques we also analyzed pathways and gene sets dysregulated in this disease usin

SUBMITTER: Levula M 

PROVIDER: S-EPMC3324479 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature