A new statistical approach to detecting differentially methylated loci for case control Illumina array methylation data.

ABSTRACT:

Motivation

As an epigenetic alteration, DNA methylation plays an important role in epigenetic controls of gene transcription. Recent advances in genome-wide scan of DNA methylation provide great opportunities in studying the impact of DNA methylation on many human diseases including various types of cancer. Due to the unique feature of this type of data, applicable statistical methods are limited and new sophisticated approaches are desirable.

Results

In this article, we propose a new statistical test to detect differentially methylated loci for case control methylation data generated by Illumina arrays. This new method utilizes the important finding that DNA methylation is highly correlated with age. The proposed method estimates the overall P-value by combining the P-value

SUBMITTER: Chen Z 

PROVIDER: S-EPMC3324514 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature