Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons.

ABSTRACT: The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion channel genes in a broad range of single neocortical neuron cell types. Using expression data from a subset of twenty-six ion channel genes in ten different neocortical neuronal types, classified according to their electrophysiological properties, morphologies and anatomical positions, we first developed an incremental Support Vector Machine (iSVM) model that prioritizes the predictive value of single and combinations of genes for the rest of the expression pattern. With this approach we could predict the expression patterns for the ten neuronal types with an average 10-fo

SUBMITTER: Khazen G 

PROVIDER: S-EPMC3324541 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature