Protein structure validation by generalized linear model root-mean-square deviation prediction.

ABSTRACT: Large-scale initiatives for obtaining spatial protein structures by experimental or computational means have accentuated the need for the critical assessment of protein structure determination and prediction methods. These include blind test projects such as the critical assessment of protein structure prediction (CASP) and the critical assessment of protein structure determination by nuclear magnetic resonance (CASD-NMR). An important aim is to establish structure validation criteria that can reliably assess the accuracy of a new protein structure. Various quality measures derived from the coordinates have been proposed. A universal structural quality assessment method should combine multiple individual scores in a meaningful way, which is challenging because of their different measuremen

SUBMITTER: Bagaria A 

PROVIDER: S-EPMC3324767 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature