FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.

ABSTRACT:

Unlabelled

The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens that protect mice from sepsis. In this study, we characterized one of them, ECOK1_0290, named FdeC (factor adherence E. coli) for its ability to mediate E. coli adhesion to mammalian cells and extracellular matrix. This adhesive propensity was consistent with the X-ray structure of one of the FdeC domains that shows a striking structural homology to Yersinia pseudotuberculosis invasin and enteropathogenic E. coli intimin. Confocal imaging analysis revealed that expression of FdeC on the bacterial surface is triggered by interaction of E

SUBMITTER: Nesta B 

PROVIDER: S-EPMC3324786 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature