Potential role of aromatase over estrogen receptor gene polymorphisms in migraine susceptibility: a case control study from North India.

ABSTRACT:

Background

The present study was undertaken to find out the role of estrogen pathway related gene polymorphisms in susceptibility to migraine in Northern Indian population. Aromatase, CYP19A1 (rs10046 and rs4646); estrogen receptors, ESR1 (rs2234693, rs1801132, rs2228480 and rs9340799) and ESR2 (rs1271572 and rs1256049) polymorphisms were selected for the present study.

Methodology/principal findings

The patients were recruited in two cohorts - primary (207) and replicative (127) along with 200 healthy controls and genotyped for various polymorphisms. Logistic regression analysis was applied for statistical analyses. The results were validated in the replicative cohort and pooled by meta analysis using Fisher's and Mantel-Haenszel test. Furthermore, Benjamini - Hochberg fals

SUBMITTER: Ghosh J 

PROVIDER: S-EPMC3325278 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature