Comprehensive resequence analysis of a 123-kb region of chromosome 11q13 associated with prostate cancer.

ABSTRACT:

Background

Genome-wide association studies of prostate cancer have identified single nucleotide polymorphism (SNP) markers in a region of chromosome 11q13.3 in men of European decent. A fine-mapping analysis with tag SNPs in the cancer genetic markers of susceptibility study identified three independent loci, marked by rs10896438, rs12793759, and rs10896449. This study further annotates common and uncommon variation across this region.

Methods

A next generation resequence analysis of a 122.9-kb region of 11q13.3(68,642,755-68,765,690) was conducted in 78 unrelated individuals of European background,1 CEPH trio, and 1 YRI trio.

Results

In total, 644 polymorphic loci were identified by our sequence analysis. Of these,166 variants—118 SNPs and 48 insertion-deletion polym

SUBMITTER: Chung CC 

PROVIDER: S-EPMC3325513 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature