Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis.

ABSTRACT:

Aim

To investigate the relationship between polymorphisms present in the vitamin D receptor (VDR) gene and colorectal cancer risk, a systematic meta-analysis of population-based studies was performed.

Methods

A total of 38 relevant reports published between January 1990 and August 2010 were identified, of which only 23 qualified for this meta-analysis based on our selection criteria. Five polymorphic variants of the VDR gene, including Cdx-2 (intron 1e) and FokI (exon 2) present in the 5' region of the gene, and BsmI (intron 8), ApaI (intron 8), and TaqI (exon 9) sites present in the 3' untranslated region (UTR), were evaluated for possible associations with colorectal cancer risk. Review manager 4.2 was used to perform statistical analyses.

Results

In the meta-analys

SUBMITTER: Bai YH 

PROVIDER: S-EPMC3325535 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature