Role of phospholipase Cε in physiological phosphoinositide signaling networks.

ABSTRACT: Receptor-initiated phospholipase C activation and generation of IP(3) and DAG are important common triggers for a diversity of signal transduction processes in many cell types. Contributing to this diversity is the existence and differential cellular and subcellular distribution of distinct phospholipase C isoforms with distinct regulatory properties. The recently identified PLCε enzyme is an isoform that is uniquely regulated by multiple upstream signals including ras-family GTP binding proteins as well as heterotrimeric G-proteins. In this review we will consider the well documented biochemical regulation of this isoform in the context of cell and whole animal physiology and in the context of other G protein-regulated PLC isoforms. These studies together reveal a surprisingly wide range

SUBMITTER: Smrcka AV 

PROVIDER: S-EPMC3325758 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature