Amphiphilic polyanhydride nanoparticles stabilize Bacillus anthracis protective antigen.

ABSTRACT: Advancements toward an improved vaccine against Bacillus anthracis, the causative agent of anthrax, have focused on formulations composed of the protective antigen (PA) adsorbed to aluminum hydroxide. However, due to the labile nature of PA, antigen stability is a primary concern for vaccine development. Thus, there is a need for a delivery system capable of preserving the immunogenicity of PA through all the steps of vaccine fabrication, storage, and administration. In this work, we demonstrate that biodegradable amphiphilic polyanhydride nanoparticles, which have previously been shown to provide controlled antigen delivery, antigen stability, immune modulation, and protection in a single dose against a pathogenic challenge, can stabilize and release functional PA. These nanoparticles dem

SUBMITTER: Petersen LK 

PROVIDER: S-EPMC3325798 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature