Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy.

ABSTRACT:

Background

Although the accumulation of white adipose tissue (WAT) is a risk factor for disease, brown adipose tissue (BAT) has been suggested to have a protective role against obesity.

Objective

We studied whether changes in BAT were related to changes in the amounts of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in children treated for malignancy.

Design

We examined the effect of BAT activity on weight, SAT, and VAT in 32 pediatric patients with cancer whose positron emission tomography-computed tomography (PET-CT) scans at diagnosis showed no BAT activity. Changes in weight, SAT, and VAT from diagnosis to remission for children with metabolically active BAT at disease-free follow-up (BAT+) were compared with those in children without visuali

SUBMITTER: Chalfant JS 

PROVIDER: S-EPMC3325837 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature