BMP4 was associated with NSCL/P in an Asian population.

ABSTRACT:

Background

The Bone Morphogenetic Protein 4 gene (BMP4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a genome wide linkage analysis of human multiplex families. BMP4 has been shown to play crucial roles in lip and palatal development in animal models. Several candidate gene association analyses also supported its potential risk for NSCL/P, however, results across these association studies have been inconsistent. The aim of the current study was to test for possible association between markers in and around the BMP4 gene and NSCL/P in Asian and Maryland trios.

Methodology/principal findings

Family Based Association Test was used to test for deviation from Mendelian assortmen

SUBMITTER: Chen Q 

PROVIDER: S-EPMC3325933 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature