Prognostic significance of miR-205 in endometrial cancer.

ABSTRACT:

Purpose

microRNAs have emerged as key regulators of gene expression, and their altered expression has been associated with tumorigenesis and tumor progression. Thus, microRNAs have potential as both cancer biomarkers and/or potential novel therapeutic targets. Although accumulating evidence suggests the role of aberrant microRNA expression in endometrial carcinogenesis, there are still limited data available about the prognostic significance of microRNAs in endometrial cancer. The goal of this study is to investigate the prognostic value of selected key microRNAs in endometrial cancer by the analysis of archival formalin-fixed paraffin-embedded tissues.

Experimental design

Total RNAs were extracted from 48 paired normal and endometrial tumor specimens using Trizol based appr

SUBMITTER: Karaayvaz M 

PROVIDER: S-EPMC3325973 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature