Genome-wide transcription analysis of clinal genetic variation in Drosophila.

ABSTRACT: Clinal variation in quantitative traits is widespread, but its genetic basis awaits identification. Drosophila melanogaster shows adaptive, clinal variation in traits such as body size along latitudinal gradients on multiple continents. To investigate genome wide transcription differentiation between North and South that might contribute to the clinal phenotypic variation, we compared RNA expression patterns during development of D. melanogaster from tropical northern and temperate southern populations using whole genome tiling arrays. We found that genes that were differentially expressed between the cline ends were generally associated with metabolism and growth, and experimental alteration of expression of a sample of them generally resulted in altered body size in the predicted directi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC3326059 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature