A mechanism-based approach for absorption modeling: the Gastro-Intestinal Transit Time (GITT) model.

ABSTRACT: Absorption models used in the estimation of pharmacokinetic drug characteristics from plasma concentration data are generally empirical and simple, utilizing no prior information on gastro-intestinal (GI) transit patterns. Our aim was to develop and evaluate an estimation strategy based on a mechanism-based model for drug absorption, which takes into account the tablet movement through the GI transit. This work is an extension of a previous model utilizing tablet movement characteristics derived from magnetic marker monitoring (MMM) and pharmacokinetic data. The new approach, which replaces MMM data with a GI transit model, was evaluated in data sets where MMM data were available (felodipine) or not available (diclofenac). Pharmacokinetic profiles in both datasets were well described by th

SUBMITTER: Henin E 

PROVIDER: S-EPMC3326175 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature