Genomics and successful aging: grounds for renewed optimism?

ABSTRACT:

Background

Successful aging depends in part on delaying age-related disease onsets until later in life. Conditions including coronary artery disease, Alzheimer's disease, prostate cancer, and type 2 diabetes are moderately heritable. Genome-wide association studies have identified many risk associated single-nucleotide polymorphisms for these conditions, but much heritability remains unaccounted for. Nevertheless, a great deal is being learned.

Methods

Here, we review age-related disease associated single-nucleotide polymorphisms and identify key underlying pathways including lipid handling, specific immune processes, early tissue development, and cell cycle control.

Results

Most age-related disease associated single-nucleotide polymorphisms do not affect coding regio

SUBMITTER: Pilling LC 

PROVIDER: S-EPMC3326244 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature