Inter-chromosomal variation in the pattern of human population genetic structure.

ABSTRACT: Emerging technologies now make it possible to genotype hundreds of thousands of genetic variations in individuals, across the genome. The study of loci at finer scales will facilitate the understanding of genetic variation at genomic and geographic levels. We examined global and chromosomal variations across HapMap populations using 3.7 million single nucleotide polymorphisms to search for the most stratified genomic regions of human populations and linked these regions to ontological annotation and functional network analysis. To achieve this, we used five complementary statistical and genetic network procedures: principal component (PC), cluster, discriminant, fixation index (FST) and network/pathway analyses. At the global level, the first two PC scores were sufficient to account for ma

SUBMITTER: Baye TM 

PROVIDER: S-EPMC3326352 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature