Interstitial lung abnormalities and reduced exercise capacity.

ABSTRACT:

Rationale

The relationship between interstitial lung abnormalities (ILA) and exercise capacity has not been comprehensively evaluated.

Objectives

To assess the validity of the 6-minute walk test in subjects with ILA, and to examine the association between ILA and 6-minute walk distance (6MWD).

Methods

Spearman correlation coefficients were used to assess the strength of the relationships between 6MWD and relevant measures of dyspnea, health-related quality of life, and pulmonary function in a cohort of 2,416 people who smoke from the COPDGene study. Unadjusted and adjusted linear and logistic regression models were used to assess the strength of the association between ILA and 6MWD.

Measurements and main results

In all subjects, and in those with ILA, 6MWD in C

SUBMITTER: Doyle TJ 

PROVIDER: S-EPMC3326424 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature