The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila.

ABSTRACT: Human neurodegenerative diseases have the temporal hallmark of afflicting the elderly population. Ageing is one of the most prominent factors to influence disease onset and progression, yet little is known about the molecular pathways that connect these processes. To understand this connection it is necessary to identify the pathways that functionally integrate ageing, chronic maintenance of the brain and modulation of neurodegenerative disease. MicroRNAs (miRNA) are emerging as critical factors in gene regulation during development; however, their role in adult-onset, age-associated processes is only beginning to be revealed. Here we report that the conserved miR

SUBMITTER: Liu N 

PROVIDER: S-EPMC3326599 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature