Using 3-D dense packing models to predict surface tension change due to protein adsorption.

ABSTRACT: Protein adsorption modeling primarily focuses on the role of the complexities and differences in the role of the protein constituents. However, experimental evidence suggests that adsorption of human blood-borne protein molecules of widely varying size and purpose is more similar than different. A model, which treats proteins as hard, non-interacting spheres, explains the observed regularity of human blood borne protein adsorption as a result of the dominant role of the solvent in the adsorption process. Here we independently evaluate the efficacy of this model, and adjust the model to a dependence on molecular volume as opposed to molecular weight. In addition, we explore the role of adsorption-induced conformation or orientation changes, and demonstrate that volume invariant changes are

SUBMITTER: Lampe JW 

PROVIDER: S-EPMC3327165 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature