Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors.

ABSTRACT: While the term 'protein structure' is commonplace, it is increasingly appreciated that proteins may not possess a single, well-defined structure: some regions of proteins are intrinsically disordered. The role these intrinsically disordered regions (IDRs) play in protein function is an area of significant interest. In particular, because proteins containing IDRs are largely involved in processes related to molecular recognition, the question arises whether IDRs are important in these recognition events. It has been observed that IDRs are enriched in transcription factors (TFs) in comparison with other proteins, and we sought to explore this enrichment more precisely, with an eye toward functional dissection of the prevalence and locations of IDRs in different classes of TFs. Specifically,

SUBMITTER: Guo X 

PROVIDER: S-EPMC3327284 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature