Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation.

ABSTRACT: The interactions between viruses and cellular autophagy have been widely reported. On the one hand, autophagy is an important innate immune response against viral infection. On the other hand, some viruses exploit the autophagy pathway for their survival and proliferation in host cells. Vaccinia virus is a member of the family of Poxviridae which includes the smallpox virus. The biogenesis of vaccinia envelopes, including the core envelope of the immature virus (IV), is not fully understood. In this study we investigated the possible interaction between vaccinia virus and the autophagy membrane biogenesis machinery. Massive LC3 lipidation was observed in mouse fibroblast cells upon vaccinia virus infection. Surprisingly, the vaccinia virus induced LC3 lipidation was shown to be independent

SUBMITTER: Moloughney JG 

PROVIDER: S-EPMC3327614 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature