Mechanical property changes during neonatal development and healing using a multiple regression model.

ABSTRACT: During neonatal development, tendons undergo a well orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. Conversely, during the repair response to injury, structural and compositional changes occur, but a mechanically inferior tendon is produced. As a result, developmental processes have been postulated as a potential paradigm for elucidation of mechanistic insight required to develop treatment modalities to improve adult tissue healing. The objective of this study was to compare and contrast normal development with injury during early and late developmental healing. Using backwards multiple linear regressions, quantitative and objective information was obtained into the structure-function relationships in tendon. Specif

SUBMITTER: Ansorge HL 

PROVIDER: S-EPMC3327817 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature