Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.

ABSTRACT:

Rationale

Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals.

Objective

Identify genetic predictors of echocardiographic phenotypes in hypertensive families.

Methods and results

A multistage genome-wide association study (GWAS) was conducted in hypertensive-ascertained black families (HyperGEN, stage I; GENOA, stage II); findings were replicated in HyperGEN white families (stage III). Echocardiograms were collected using a common protocol, and participants were genotyped with the Affymetrix Genome-Wide Human SNP 6.0 Array. The following were analyzed using mixed models adjusted for ancestry: in stages I and II, 1258 and 989 blacks, respectively; and in stage III, 131

SUBMITTER: Arnett DK 

PROVIDER: S-EPMC3328104 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature