Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.

ABSTRACT: Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell type-specific transcriptional programs; consequently, transcriptional regulatory factors are useful markers of emerging cellular complexity, and their expression patterns provide insights into the regulatory mechanisms at play. We performed a comprehensive genome-scale in situ expression screen of 921 transcriptional regulators in the developing mammalian urogenital system. Focusing on the kidney, analysis of regional-specific expression patterns identified novel markers and cell types associated with development and patterning of the urinary system. Furthermore, promoter

SUBMITTER: Yu J 

PROVIDER: S-EPMC3328182 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature