Association of factor V gene polymorphism with arteriovenous graft failure.

ABSTRACT:

Background

Dialysis grafts fail due to recurrent stenosis and thrombosis. Vasoactive and prothrombotic substances affecting intimal hyperplasia or thrombosis may modify graft outcomes.

Study design

Genetic polymorphisms association study of patients enrolled in a multicenter randomized clinical trial.

Setting & participants

354 Dialysis Access Consortium (DAC) Study patients receiving a new graft with DNA samples obtained. Participants were randomly assigned to treatment with aspirin plus dipyridamole versus placebo.

Predictor

DNA sequence polymorphisms for the following candidate genes and their interaction with the study intervention: methylenetetrahydrofolate reductase (MTHFR), heme oxygenase 1 (HO-1), factor V (F5), transforming growth factor β1 (TGFβ1), kl

SUBMITTER: Allon M 

PROVIDER: S-EPMC3328616 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature