Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.

ABSTRACT:

Objectives

Systemic lupus erythematosus (SLE) is a chronic multisystem genetically complex autoimmune disease characterised by the production of autoantibodies to nuclear and cellular antigens, tissue inflammation and organ damage. Genome-wide association studies have shown that variants within the major histocompatibility complex (MHC) region on chromosome 6 confer the greatest genetic risk for SLE in European and Chinese populations. However, the causal variants remain elusive due to tight linkage disequilibrium across disease-associated MHC haplotypes, the highly polymorphic nature of many MHC genes and the heterogeneity of the SLE phenotype.

Methods

A high-density case-control single nucleotide polymorphism (SNP) study of the MHC region was undertaken in SLE cohorts of S

SUBMITTER: Fernando MM 

PROVIDER: S-EPMC3329227 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature